Исследование процесса биомиметической золь-гель минерализации полисахаридов с использованием новых биосовместимых кремнийсодержащих полиолатных прекурсоров

Аннотация

In this work is demonstrated that water-soluble biocompatible polyolate precursors of tetrakis(2,3-dihydroxypropoxy)silane Si[OCH2CH(OH)CH2(OH)]4 (silicon tetraglycerolate), tetrakis(2-hydroxypropoxy)silane Si[OCH2CH(OH)CH3]4 (silicon tetra(propylene glycolate)), and tetrakis(ω-hydroxypolyethylene glyсoxy)silane Si(O[CH2CH2O]8H)4 (silicon tetra(polyethylene glycolate)) can be successfully utilized in biomimetical mineralization of polysaccharides of different nature. By the example of chitosan (cationic), xanthan gum (anionic), and hydroxyethyl cellulose (uncharged) polysaccharides, an accelerating effect on the gelation has been demonstrated and a stabilizing effect has been revealed on the hydrogels formed as transparent monoliths showing resistance to syneresis. The difference in the reactivity of precursors leads to the peculiarities of the gelation process in the presence of the polysaccharides under study, as well as to the difference in the composition of the formed products. The sol-gel process utilized to obtain the silicon–polysaccharide-containing hydrogels proceeds under the mild conditions with no catalyst or any organic solvent, and thus can be regarded as belonging to the green chemistry methods.
Based on the established regularity, in practical terms, methods have been developed for the synthesis of innovative dosage forms – dental films. This films have been obtained using polyolates (glycerolates) of silicon, polysaccharides of natural origin (chitosan) and a synthetic polymer (polyvinylpyrrolidone). Dental films of this composition are not described in the scientific and patent literature. The use of dental films in medical practice is currently extremely popular and promising.