Электрохимические сенсоры на основе углеродных наноматериалов для количественного определения потенциального лекарственного вещества 5-метил-6-нитро-7-оксо-1,2,4-триазоло[1,5-a] пиримидинид аргинина моногидрата
Аннотация
«Electrochemical sensors based on carbon nanomaterials for the quantitative determination of the potential drug 5-methyl-6-nitro-7-oxo-1,2,4-triazolo [1,5-a] pyrimidinide arginine monohydrate».
Pages 75, figures 25, tables 23, bibliographic names 28.
Key words: PHARMACEUTICAL SUBSTANCE "TRIAZIDE", THICK-FILM CARBON-CONTAINING ELECTRODE, MODIFIED ELECTRODE, CARBON BLACK, CARBON NANOTUBES, VOLTAMPEROMETRY, IMPEDANCE SPECTROSCOPY.
The object of the study was the drug 5-methyl-6-nitro-7-oxo-1,2,4-triazolo [1,5-a] pyrimidinide arginine monohydrate with the code name «Triazid» (TD).
Objective: development of a sensitive electrochemical sensor for the quantitative determination of the medicinal substance 5-methyl-6-nitro-7-oxo-1,2,4-triazolo [1,5-a] pyrimidinide of arginine monohydrate.
The possibility of using thick-film carbon-containing electrodes for voltammetric determination of the test substance is shown.
The effect of modification of the surface of thick-film electrodes on their electrochemical characteristics was studied for the quantitative determination of the drug in the test solution by the methods of cyclic voltammetry, direct voltammetry in the square-wave mode, electrochemical impedance spectroscopy, and scanning electron microscopy.
The influence of the shelf life of an electrochemical sensor for the quantitative determination of TD by direct voltammetry in a square-wave mode and electrochemical impedance spectroscopy has been investigated.
A sensitive electrochemical sensor was selected for the quantitative determination of TD.
Statistical processing of the analysis results has been performed.
Voltammetric determination of TD in the pharmaceutical substance «Triazid» was carried out. According to OFS.1.1.0012.15 and OFS OFS.1.1.0013.15 of the State Pharmacopoeia of the Russian Federation of the XIII edition, it was concluded that the analytical method for quantitative determination of TD in the pharmaceutical substance «Triazid» meets the stated acceptance criteria.
Pages 75, figures 25, tables 23, bibliographic names 28.
Key words: PHARMACEUTICAL SUBSTANCE "TRIAZIDE", THICK-FILM CARBON-CONTAINING ELECTRODE, MODIFIED ELECTRODE, CARBON BLACK, CARBON NANOTUBES, VOLTAMPEROMETRY, IMPEDANCE SPECTROSCOPY.
The object of the study was the drug 5-methyl-6-nitro-7-oxo-1,2,4-triazolo [1,5-a] pyrimidinide arginine monohydrate with the code name «Triazid» (TD).
Objective: development of a sensitive electrochemical sensor for the quantitative determination of the medicinal substance 5-methyl-6-nitro-7-oxo-1,2,4-triazolo [1,5-a] pyrimidinide of arginine monohydrate.
The possibility of using thick-film carbon-containing electrodes for voltammetric determination of the test substance is shown.
The effect of modification of the surface of thick-film electrodes on their electrochemical characteristics was studied for the quantitative determination of the drug in the test solution by the methods of cyclic voltammetry, direct voltammetry in the square-wave mode, electrochemical impedance spectroscopy, and scanning electron microscopy.
The influence of the shelf life of an electrochemical sensor for the quantitative determination of TD by direct voltammetry in a square-wave mode and electrochemical impedance spectroscopy has been investigated.
A sensitive electrochemical sensor was selected for the quantitative determination of TD.
Statistical processing of the analysis results has been performed.
Voltammetric determination of TD in the pharmaceutical substance «Triazid» was carried out. According to OFS.1.1.0012.15 and OFS OFS.1.1.0013.15 of the State Pharmacopoeia of the Russian Federation of the XIII edition, it was concluded that the analytical method for quantitative determination of TD in the pharmaceutical substance «Triazid» meets the stated acceptance criteria.