2-(адамант-1-ил)-пиразоло[1,5-а]пиримидины и 7-(адамант-1-ил)-пиразоло[5,1-с][1,2,4]триазины: синтез и свойства
Аннотация
В настоящей работе разработаны методы получения новых соединений, совмещающих адамантильный фрагмент и пиразоло[1,5-a]пиримидиновый или пиразоло[5,1-c][1,2,4]триазиновый скаффолды. Проведён анализ литературы, содержащей информацию о полезной биологической активности целевых соединений. Соединения охарактеризованы методами ЯМР 1Н и 13С спектроскопии, масс-спектрометрии, ИК-спектроскопии, данными элементного анализа. Получены результаты исследований на биологическую активность соединений в отношении SARS-CoV-2 и гриппа А. Проведён сравнительный анализ биологической активности.
In this work, methods have been developed for the preparation of new compounds combining the adamantile fragment and pyrazolo[1,5-a]pyrimidine or pyrazolo[5,1-c][1,2,4]triazine scaffolds. An analysis of the literature containing information on the beneficial biological activity of the target compounds has been carried out. The compounds were characterized by 1H NMR, 13C NMR spectroscopy, mass-spectrometry, IR-spectroscopy, and elemental analysis data. The results of studies on the biological activity of compounds in relation to SARS-CoV-2 and influenza A. A comparative analysis of biological activity was carried out.
In this work, methods have been developed for the preparation of new compounds combining the adamantile fragment and pyrazolo[1,5-a]pyrimidine or pyrazolo[5,1-c][1,2,4]triazine scaffolds. An analysis of the literature containing information on the beneficial biological activity of the target compounds has been carried out. The compounds were characterized by 1H NMR, 13C NMR spectroscopy, mass-spectrometry, IR-spectroscopy, and elemental analysis data. The results of studies on the biological activity of compounds in relation to SARS-CoV-2 and influenza A. A comparative analysis of biological activity was carried out.