Производные азоло[1,5-a]пиримидинов и их аналоги, как перспективные противоопухолевые препараты
Аннотация
В рамках данной работы составлен аналитический обзор литературы по сигнальным путям как мишеням для тагретной терапии. Проведен ряд экспериментов по оценке жизнеспособности и пролиферативной активности опухолевых и нормальных клеток в условиях присутствия различных доз производных азоло[1,5-а]пиримидинов. Определена цитотоксичность производных азоло[1,5-а]пиримидинов.
This work contains an analytical review of the literature on signaling pathways as targets for tagret therapy. A number of experiments were carried out to assess the viability and proliferative activity of tumor and normal cells in the presence of various doses of azolo [1,5-a] pyrimidine derivatives. The cytotoxicity of azolo [1,5-a] pyrimidine derivatives was determined.
This work contains an analytical review of the literature on signaling pathways as targets for tagret therapy. A number of experiments were carried out to assess the viability and proliferative activity of tumor and normal cells in the presence of various doses of azolo [1,5-a] pyrimidine derivatives. The cytotoxicity of azolo [1,5-a] pyrimidine derivatives was determined.