Влияние новых азолопиримидиновых комплексов на жизнеспособность культивируемых клеток злокачественных новообразований
Аннотация
В рамках данной работы составлен аналитический обзор литературы о противоопухолевой терапии, наиболее важных сигнальных путях, задействованных в опухолевом генезе и последний достижениях, связанных с синтезом новых противоопухолевых агентов. Проведен ряд экспериментов по исследованию цитотоксического эффекта соединений азолопиримидинового ряда на культивируемых опухолевых клетках. Выявлены наиболее перспективные молекулы, рекомендуемые к дальнейшему изучению на предмет механизма действия.
Within the framework of this work, an analytical review of the literature on anticancer therapy, the most important signaling pathways involved in tumor genesis, and the latest advances in the synthesis of new anticancer agents was compiled. A number of experiments were carried out to study the cytotoxic effect of compounds of the azolopyrimidine series on cultured tumor cells. The most promising molecules have been identified, which are recommended for further study for their mechanism of action.
Within the framework of this work, an analytical review of the literature on anticancer therapy, the most important signaling pathways involved in tumor genesis, and the latest advances in the synthesis of new anticancer agents was compiled. A number of experiments were carried out to study the cytotoxic effect of compounds of the azolopyrimidine series on cultured tumor cells. The most promising molecules have been identified, which are recommended for further study for their mechanism of action.