Исследование антиоксидантных свойств препаратов сочетанного действия
Аннотация
Study of antioxidant properties of combined action.
Pages. 64, fig. 26, tab. 8, sources 33.
REACTIVE OXYGEN SPECIES, ANTIOXIDANT, POTENTIOMETRY, FREE RADICALS, ANTIRADICAL CAPACITY, TRIAZOLES, IMIDAZOLES, VIRAL DISEASES, ALZHEIMER'S DISEASE, NEURODEGENERATIVE DISEASES, POLYPHENOLS.
Objective of the work: comprehensive study of integral antioxidant parameters of combined action drugs for the treatment of viral and neurodegenerative diseases.
We have considered ways to form free radicals and antioxidant approaches in therapy of various diseases.
In the process of work we investigated the antioxidant parameters adducts of triazole and imidazoles modified with polyphenols. Particularly, the determination of antioxidant capacity with oxidizing agents of a radical (2,2'-azobis (2-methylpropionamidine) dihydrochloride (AAPH)) and non-radical nature (K3[Fe(CN)6]/K4[Fe(CN)6) was performed by using the potentiometric method.
Stoichiometric inhibition coefficients of the studied triazoles take values from 0 to 15, imidazoles – from 0 to 5, depending on the number of active groups in the antioxidant molecule, their location and the mechanism of chain termination on the antioxidant.
Spectrophotometric studies were carried out using the reactions of the interaction of antioxidants with a stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and reagent Folin-Ciocalteu to confirm the correctness of the results.
Pages. 64, fig. 26, tab. 8, sources 33.
REACTIVE OXYGEN SPECIES, ANTIOXIDANT, POTENTIOMETRY, FREE RADICALS, ANTIRADICAL CAPACITY, TRIAZOLES, IMIDAZOLES, VIRAL DISEASES, ALZHEIMER'S DISEASE, NEURODEGENERATIVE DISEASES, POLYPHENOLS.
Objective of the work: comprehensive study of integral antioxidant parameters of combined action drugs for the treatment of viral and neurodegenerative diseases.
We have considered ways to form free radicals and antioxidant approaches in therapy of various diseases.
In the process of work we investigated the antioxidant parameters adducts of triazole and imidazoles modified with polyphenols. Particularly, the determination of antioxidant capacity with oxidizing agents of a radical (2,2'-azobis (2-methylpropionamidine) dihydrochloride (AAPH)) and non-radical nature (K3[Fe(CN)6]/K4[Fe(CN)6) was performed by using the potentiometric method.
Stoichiometric inhibition coefficients of the studied triazoles take values from 0 to 15, imidazoles – from 0 to 5, depending on the number of active groups in the antioxidant molecule, their location and the mechanism of chain termination on the antioxidant.
Spectrophotometric studies were carried out using the reactions of the interaction of antioxidants with a stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and reagent Folin-Ciocalteu to confirm the correctness of the results.